MovDisordV3, Main, Exploration, bibRecord, 000F75

Subthalamic Neuronal Responses to Cortical Stimulation

Identifieur interne : 000F75 ( Main/Exploration ); précédent : 000F74; suivant : 000F76

Subthalamic Neuronal Responses to Cortical Stimulation

Auteurs : Marcus L. F. Janssen [Pays-Bas] ; Daphne G. M. Zwartjes [Pays-Bas] ; Yasin Temel [Pays-Bas] ; Vivianne Van Kranen-Mastenbroek [Pays-Bas] ; Annelien Duits [Pays-Bas] ; Lo J. Bour [Pays-Bas] ; Peter H. Veltink [Pays-Bas] ; Tjitske Heida [Pays-Bas] ; Veerle Visser-Vandewalle [Pays-Bas]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0198674

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Neurophysiologie, Noyau sousthalamique, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Nervous system diseases, Neurophysiology, Parkinson disease, Subthalamic nucleus.

Abstract

Background: Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation. Methods: We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique. Results: Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (˜5-4.5 ms) and subsequent inhibition (45-105 ms) were seen. The lateral electrode also showed a late excitation (˜125-160 ms). Focal seizures were observed following motor cortex stimulation. Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.

Affiliations:

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Le document en format XML

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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>Maastricht Institute for Neuromodulative Development (MIND)</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Nervous system diseases</term>
<term>Neurophysiology</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Neurophysiologie</term>
<term>Noyau sousthalamique</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Deep brain stimulation of the subthalamic nucleus alleviates motor symptoms in Parkinson's disease patients. However, some patients suffer from cognitive and emotional changes. These side effects are most likely caused by current spread to the cognitive and limbic territories in the subthalamic nucleus. The aim of this study was to identify the motor part of the subthalamic nucleus to reduce stimulation-induced behavioral side effects, by using motor cortex stimulation. Methods: We describe the results of subthalamic nucleus neuronal responses to stimulation of the hand area of the motor cortex and evaluate the safety of this novel technique. Results: Responses differed between regions within the subthalamic nucleus. In the anterior and lateral electrode at dorsal levels of the subthalamic nucleus, an early excitation (˜5-4.5 ms) and subsequent inhibition (45-105 ms) were seen. The lateral electrode also showed a late excitation (˜125-160 ms). Focal seizures were observed following motor cortex stimulation. Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
</country>
<region><li>Hollande-Septentrionale</li>
<li>Overijssel</li>
</region>
<settlement><li>Amsterdam</li>
<li>Enschede</li>
</settlement>
<orgName><li>Université de Twente</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><noRegion><name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name>
</noRegion>
<name sortKey="Bour, Lo J" sort="Bour, Lo J" uniqKey="Bour L" first="Lo J." last="Bour">Lo J. Bour</name>
<name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name>
<name sortKey="Duits, Annelien" sort="Duits, Annelien" uniqKey="Duits A" first="Annelien" last="Duits">Annelien Duits</name>
<name sortKey="Heida, Tjitske" sort="Heida, Tjitske" uniqKey="Heida T" first="Tjitske" last="Heida">Tjitske Heida</name>
<name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name>
<name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name>
<name sortKey="Janssen, Marcus L F" sort="Janssen, Marcus L F" uniqKey="Janssen M" first="Marcus L. F." last="Janssen">Marcus L. F. Janssen</name>
<name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name>
<name sortKey="Kranen Mastenbroek, Vivianne Van" sort="Kranen Mastenbroek, Vivianne Van" uniqKey="Kranen Mastenbroek V" first="Vivianne Van" last="Kranen-Mastenbroek">Vivianne Van Kranen-Mastenbroek</name>
<name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name>
<name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name>
<name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name>
<name sortKey="Temel, Yasin" sort="Temel, Yasin" uniqKey="Temel Y" first="Yasin" last="Temel">Yasin Temel</name>
<name sortKey="Veltink, Peter H" sort="Veltink, Peter H" uniqKey="Veltink P" first="Peter H." last="Veltink">Peter H. Veltink</name>
<name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name>
<name sortKey="Visser Vandewalle, Veerle" sort="Visser Vandewalle, Veerle" uniqKey="Visser Vandewalle V" first="Veerle" last="Visser-Vandewalle">Veerle Visser-Vandewalle</name>
<name sortKey="Zwartjes, Daphne G M" sort="Zwartjes, Daphne G M" uniqKey="Zwartjes D" first="Daphne G. M." last="Zwartjes">Daphne G. M. Zwartjes</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Subthalamic Neuronal Responses to Cortical Stimulation

Subthalamic Neuronal Responses to Cortical Stimulation

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